The growth rate of tubercle bacilli from South Indian and British patients.
Bhatia, A.L.; Ramachandran, K.
Indian Journal of Medical Research; 1962; 50; 335-342.
Cultures of tubercle bacilli from Indian patients have been shown to be, on average, less virulent in the guinea-pig and to have a wider range of virulence than cultures obtained from British patients (Frimodt-Moller, Mathew and Barton, 1956; Mitchison et al ., 1960; Bhatia et al ., 1961). In this study of Bhatia et al ., (loc.cit) about one-third of the Indian cultures were as virulent as British cultures, the remainder being less virulent. In these studies the extent of disease in the organs of the guinea pig was scored at intervals after the intramuscular injection of the organisms. In consequence, the measure of virulence was based upon the rate of development of the lesions and by inference, the rate of multiplication of the bacilli in the organs. It was, therefore, considered of interest to compare the growth rates in vitro of Indian and British cultures of tubercle bacilli.
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