Combination of results from several 2 x 2 contingency tables.
Radhakrishna, S.
Biometrics; 1965; 21; 86-98.
After reviewing various methods commonly used to combine the results from several 2 x 2 contingency tables, Cochran (1954) suggested a new approach and test of significance. Although the method is general, it will for convenience be discussed against the background of clinical trials. Briefly, it consists of calculating a weighted average of the differences in efficacy between the two treatments in the various 2 x 2 tables, the weights being based on some consideration of optimality.
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