Cycloserine plus ethionamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy.
Ramakrishnan, C.V.; Devadatta, S.; Evans, C.; Kamat, S.R.; Menon, N.K.; Radhakrishna, S.; Rajagopalan, S.; Stott, H.
Tubercle; 1967; 48; 114-127.
Fifty patients with chronic pulmonary tuberculosis and cultures resistant to isoniazid were treated with a daily regimen of ethionamide (500 mg.) plus cycloserine in an intended dose of 500 mg., but possibly less because of deterioration. Most of the patients had streptomycin-resistant cultures also. Forty-three had received two previous regimens of chemotherapy.
During the year, 10 (20%) patients became un-cooperative and refused further treatment, and in two the regimen was stopped on account of drug toxicity. Of the remaining 38 patients, 58% had bacteriologically quiescent disease at one year, 65% showed radiographic improvement and 61% had cavity closure or less cavitation than on admission.
Major toxicity to ethionamide occurred in two patients and to cycloserine in two patients; minor side effects were reported by 18 patients.
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