Method for the estimation of acetylisoniazod in urine.
Venkataraman, P.; Eidus, L..; Tripathy, S.P.
Tubercle; 1968; 49; 210-216 and Indian Journal of Medical Research; 1968; 56; 895-902.
A method for the estimation of acetylisoniazid in urine is described. It is simple, sensitive and reliable and follows Beer's law between 10 m g./ml. and 40 m g./ml. It yields complete recovery of acetylisoniazid from specimens of urine to which the compound has been added in known concentrations. In this procedure, the drug-containing urine itself serves as the blank if the reagents are mixed first and then the urine added.
Isoniazid in high concentrations produces a colour reaction in this method. This interference is eliminated by potassium permanganate which destroys isoniazid but not acetylisoniazid under the conditions of the estimation.
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