A note on the relapse rate over a four-year period in patients with quiescent pulmonary tuberculosis following treatment with reserve regimens.
Velu, S.; Sambamoorthy, S.
Tubercle; 1968; 49; 410-412 and Indian Journal of Tuberculosis; 1969; 16; 83-84.
Fifty patients, all of whom had failed on previous treatment with isoniazid or isoniazid plus PAS, attained bacteriologically quiescent disease at the end of the one year of daily treatment with streptomycin (1 g.) plus pyrazinamide (1-1.75 g.). Over a four-year period of follow-up (during which 38 continued to receive the regimen for 1-14 months), only one had a bacteriological relapse.
Twenty patients, of whom 18 had failed on two previous chemotherapeutic regimens, attained bacteriologically quiescent disease at the end of one year of daily treatment with ethionamide (500 mg.) plus cycloserine (in an intended dose of 500 mg.). Over a four-year period of follow-up (during which nine continued to receive the regimen for 1-14 months), four had a bacteriological relapse.
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