Classification of subjects as slow or rapid inactivators of isoniazid, based on the ratio of the urinary excretion of acetylisoniazid to isoniazid.
Venkataraman, P.; Menon, N.K.; Nair, N.G.K.; Radhakrishna, S.; Chandra Ross; Tripathi, S.P.
Tubercle; 1972; 53; 84-91 and Indian Journal of Medical Research; 1972; 60; 685-693.
Following an intramuscular injection of isoniazid 3 mg/kg body-weight, the urinary excretion of isoniazid and acetylisoniazid during the periods 0-1, 1-2, 2-3 and 3-4h was determined for 124 patients with pulmonary tuberculosis. On the same occasions, the serum isoniazid concentration at 4½ h was determined by microbiologic assay. The ratios of acetylisoniazid to isoniazid in the urine collections at 2, 3 and 4 h were bimodally distributed. Rules were derived from these ratios for classifying subjects as slow or rapid inactivators of isoniazid. There was 100% agreement between the classification based on each of these ratios and that based on the serum isoniazid concentration at 4½ h.
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