Classification of subjects as slow or rapid inactivators of isoniazid oral administration of a slow-release preparation of isoniazid and determination of the ratio of acetylisoniazid to isoniazid in urine.
Kailasam, S.; Chandra Immanuel; Nair, N.G.K.; Radhakrishna, S.; Tripathy, S.P.
Indian Journal of Medical Research; 1975; 63; 323-328.
A simple method for classifying subjects as slow or rapid inactivators of isoniazid has been evaluated on large numbers of patients. The method consists of determining the ratio of acetylisoniazid to isoniazid in a 24-26 h. urine collection following the oral administration of a slow-release preparation of isoniazid 30 mg./kg. body-weight. In a group of 101 patients, there was 100 per cent agreement between the classification based on this method and that based on a standard method, consisting of estimation of the serum isoniazid concentration 4½ h. after an intramuscular dose of ordinary isoniazid 3 mg./kg. body-weight. Subsequent studies in other patients have confirmed that the method is efficient, and demonstrated that the classification is highly reproducible.
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