Cycloserine plus ethionamide plus pyrazinamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy.
Ramakrishnan, C.V.; Parthasarathy, R.; Sambamoorthy, S.; Somasundaram, P.R.; Subbammal, S.
Indian Journal of Medical Research; 1976; 64; 76-82.
The results of treatment with a daily triple-drug regimen of cycloserine plus ethionamide plus pyrazinamide in 62 patients with chronic drug-resistant pulmonary tuberculosis are described. Of 51 patients who could be assessed, 37 (73 per cent) had a favourable bacteriological response at 1 year; 2 had a bacteriological relapse by 36 months. Drug toxicity requiring clinical action occurred in 22 (35 per cent) of the 62 patients. Ethionamide was the main drug accounting for toxicity and had to be terminated in 7 patients.
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