Methods for the estimation of pyrazinamide and pyrazinoic acid in body fluids.
Prema Gurumurthy; Nair, N.G.K.; Raghupati Sarma, G.
Indian Journal of Medical Research; 1980; 71; 129-134.
Methods for the estimation of pyrazinamide in serum and of pyrazinamide and pyrazinoic acid in urine using an anion-exchange resin (Dowex-1) have been described. Recoveries were quantitative, and the sensitivity was 5 µg/ml for all 3 estimations. In serum, pyrazinoic acid at a concentration of 50 µg/ml did not interfere with the estimation of pyrazinamide. In urine, pyrazinamide and pyrazinoic acid could be separated from each other and estimated even when the 2 compounds were present together at concentrations of 2000 µg/ml each.
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