Assay of ethambutol in pharmaceutical preparations.
Prema Gurumurthy; Narayana, A.S.L.; Raghupati Sarma, G.; Somasundaram, P.R.
Lung India; 1984; II; 143-145.
Ethambutol tablets of 200 and 400 mg denominations were assayed by the standard non-aqueous titration method and a simpler calorimetric method. With the titrimetric method, assay values, appreciably higher than the stated cotent (117% or more), were obtained with the products of 4 companies, while all the values were with on 6% of the stated content by the calorimetric method. Rifampicin and pyrazinamide interfered with the estimation of ethambutol by both methods; isoniazid, however, caused an overestimation with the titrimetric method only.
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