In vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to trifluoperazine.

Selvakumar, N.; Vanaja Kumar; Krishnamurthy, P.V.; Prabhakar, R; Murthy, P.S.

Current Science; 1997; 73; 79-80.

The reference strain, Mycobacterium tuberculosis H 37 Rv, 19 drug-sensitive and 15 drug resistant clinical isolates of M. tuberculosis were tested for their in vitro susceptibility to trifluoperazine (TFP), an antipsychotic drug, by both dilution method. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of TFP against M. tuberculosis H 37 Rv were 8 and 32 mg/l, respectively. The distribution of the sensitive and resistant isolates, with respect to the MIC of TFP, was similar. The distribution of the sensitive and resistant isolates, with respect to the MBC of TFP, was different and the difference was statistically significant. The findings suggest that TFP is more bactericidal to drug-resistant isolates than to the sensitive isolates.

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