HLA antigen profile in pulmonary tuberculosis patients and their spouses.
Selvaraj, P.; Uma, H.; Reetha, A.M.; Kurian, S.M.; Theresa Xavier; Prabhakar, R.; Narayanan, P.R.
Indian Journal of Medical Research; 1998; 107-1 155-158.
HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n=209) and their spouses (family contacts) (n=50) and healthy volunteers (n=72). An increased frequency of HLA-A10, B7, -B15, DR2 and DQ1 was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n=122). However, a significant increase was seen only with HLA-DR2 (p<0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (p<0.005; Pc < 0.015; Relative Risk 2.8). Among the spouses and their corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-AL19, B8, B17, B35, DR5 and DR6 were seen in PTB as compared to control groups. The present study suggested that HLA-DR2 and DQ1 genes/gene products may be associated with the susceptibility to tuberculosis either alone or in combination with other HLA or Non-HLA genes.
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