NRAMP1 gene polymorphism in pulmonary and spinal tuberculosis.
Selvaraj, P.; Chandra, G.; Kurian, S.M.; Reetha, A.M.; Charles, N.; Narayanan, P.R.
Current Science; 2002; 82; 451-454 .
NRAMP1 gene polymorphisms such as 823 C/T (exon 8), deletion of TGTG in the 3' -UTR (3' untranslated region) and D543N G/A (exon 15) were studied to find out whether the gene polymorphic variants are associated with the susceptibility or resistance to tuberculosis (TB). The study was carried out in pulmonary ( n = 100), spinal TB patients ( n = 57) and control subjects ( n = 112). No difference was observed in the variant genotype frequencies of NRAMP1 - 823 C/T, TGTG+/del and D543N G/A polymorphisms. However, a trend towards an increased frequency of the variant genotype 823 C/T (heterozygotes) was observed in pulmonary TB patients than control and spinal TB patients (odds ratio (OR) : 1.6; confidence Interval (CI) 0.74-3.4). A trend towards an increased frequency of the variant genotype TGTG del/del of 3'-UTR was observed in control subjects than pulmonary and spinal TB patients (OR : 0.48; CI: 0.10-1.78; OR: 0.42; CI : 0.04-2.12, respectively). The above trends were not significant. The study suggests that NRAMP1 gene may not be associated with the susceptibility to pulmonary and spinal TB in the Indian population. Major Histocompatibility Complex (MHC) and other non-MHC gene polymorphic variants may be associated.
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