BamH I polymorphism of human cytochrome P 450 gene, CYP2D6, in quiescent and relapse patients of pulmonary tuberculosis.

Chandra, G.; Selvaraj, P.; Reetha, A.M.; Narayanan, P.R.

Biomedicine; 2003; 23; 27-32.

BamH I polymorphism of the human cytochrome P 450 gene, CYP2D6, which encodes drug metabolizing enzyme, was studied to find out whether variant genotypes of this gene are associated with the susceptibility or resistance to bacteriological relapse of pulmonary tuberculosis after stopping treatment with short-course chemotherapy of 6-8 months duration. The study was carried out in control subjects (n=158), patients with pulmonary tuberculosis (n=154), patients with bacteriological relapse (n=50) and quiescent patients (n=50). No difference in the frequency of variant genotypes of BamH I polymorphism of CYP2D6 gene was observed between pulmonary TB patients and control subjects. A trend towards an increased frequency of 22 genotype (homozygous for infrequent allele 2) was observed in bacteriological relapse patients than quiescent patients (odds ratio, OR: 2). Similar increase was observed in male relapse patients than male quiescent patients (OR: 2.2). The present study suggests that 22 genotype of BamH I polymorphism of CYP2D6 of human cytochrome P 450 gene either alone or in combination with closely linked genes may be associated with bacteriological relapse especially in male patients of pulmonary tuberculosis.

Keywords : BamH I, CYP2D6 gene, polymorphism, pulmonary TB

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