Extensively drug-resistant tuberculosis: experience at the Tuberculosis Research Cemtre, Chennai , India .

Thomas, A.; Joseph, P.; Nair, D.; Rao, D.V.B.; Rekha, V.V.B.; Selvakumar, N.; Jaggarajamma, K.; Balambal, R.

International Journal of Tuberculosis and Lung Disease; 2011; 15; 1323-1325.   

Summary: Ten extensively drug-resistant tuberculosis (XDR-TB) patients were identified among 104 human immunodeficiency virus negative multidrug-resistant tuberculosis (MDR-TB) patients treated at the Tuberculosis Research Centre, Chennai , India , in two different cohorts between 1999–2003 and 2006–2007. They were managed with individualised treatment regimens. At the time of diagnosis of MDR-TB, one patient had XDR-TB and three had initial ofloxacin resistance. One patient who had had a lobectomy in addition to chemotherapy became bacteriologically negative, three died, three defaulted and the remaining three, who are bacteriologically positive, are still continuing treatment. Although based on a small number of patients, our results have not been encouraging.

Keywords: T uberculosis; drug resistance; XDR-TB; second-line drugs; management

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