Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.

Unissa, A.N.; Sudha, S.; Selvakumar, N.; Hassan, S.

Bioinformation; 2011; 7; 107-111.             

Abstract: AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis ( Mtb ). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.

Keywords: M. tuberculosis; modeling; docking; AccD6; INH; INADH; acetyl-CoA

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