RMP exposure is lower in HIV-infected TB patients receiving intermittent than daily anti-tuberculosis treatment.

Hemanth, A.K.; Narendran, G.; Kumar, R.S.; Ramachandran, G.; Sekar, L.; Raja, K.; Swaminathan, S.

International Journal of Tuberculosis and Lung Disease; 2015; 19; 805-807.     

Summary: We compared the pharmacokinetics of rifampicin (RMP) during daily and intermittent (thrice weekly) anti-tuberculosis treatment in human immunodeficiency virus infected tuberculosis patients. Patients treated with a thrice-weekly regimen had significantly lower plasma peak concentration, area under the time concentration curve from 0 to 24 h and higher oral clearance of RMP than those treated with the daily regimen. The median values were respectively 3.7 and 6.4 m g/ml ( P < 0.001), 20.7 and 29.4 m g/ml.h ( P = 0.03) and 21.7 and 15.3 ml/ min ( P = 0.03).

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