Bioactivity of selected seaweeds from gulf of Mannar, South-east cost of India .

Amudha; Prabuseenivasan; Naga Harika; Kumar V.

Journal of Coastal Life Medicine; 2015; 3; 52-55.         

Abstract: Objective: To evaluate antimicrobial and antimycobacterial activity of three seaweeds [ Gelidiella acerosa (G. acerosa) , Turbinaria conoides (T. conoides) and Sargassum wightii (S. wightii) ] from Gulf of Manner .

Methods: Three seaweeds G. acerosa , T. conoides and S. wightii were collected from Gulf of Mannar, South-East Coast of India . Solvent extraction of the selected seaweeds was done using hexane and ethanol. These extracts were tested for antibacterial activity against four bacterial strains ( Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis and Staphylococcus aureus ) by disc diffusion method. The active extracts of T. conoides were tested for antimycobacterial activity by luciferase reporter phage assay at two different concentrations (100 µg/mL and 500 µg/mL).

Results: Among the tested seaweeds, ethanol extract of T. conoides showed maximum antibacterial activity against Bacillus subtilis and Staphylococcus aureus followed by hexane extract at concentration of 1 mg/disc. The remaining two seaweeds ( G. Acerosa and S. wightii ) did not show any activity. The ethanol extract of T. conoides exhibited maximum antimycobacterial activity (87.33%) followed by hexane extract (74.68%) against Mycobacterium tuberculosis H37Rv at 500 µg/mL.

Conclusions: Ethanol extract of T. conoids showed both antibacterial and antimycobacterial activity. Further photochemical studies are needed to identify the active antimycobacterial agents.

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