Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid.
Parthasarathy, R.; Devadatta, S.; Wallace Fox; Krishnaswami, K.V.; Radhakrishna, S.; Somasundaram, P.R.; Tripathy, S.P.
Tubercle; 1976; 57; 115-121.
'Double-blind' studies were carried out to assess the incidence of immediate adverse reactions to different doses of a slow-release preparation of isoniazid (matrix isoniazid). Individual doses of 30 mg/kg matrix isoniazid were well-tolerated but higher doses resulted in giddiness, the incidence being dose-related. The giddiness was characterized by a late onset and was usually present even at 24 hours. A few patients complained of gastro-intestinal symptoms. It is concluded that matrix isoniazid can be given to Madras patients in doses of 30-40 mg/kg without risk of an undue incidence of immediate adverse reactions.
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