Classification of subjects as slow or rapid inactivators of isoniazid based on the ratio of acetylisoniazid to isoniazid in urine determined by a simple calorimetric method.
Raghupati Sarma, G.; Kailasam, S.; Kannapiran, M.; Krishnaswami, K.V.; Leila Thomas; Nair, N.G.K.; Narayana, A.S.L.
Indian Journal of Medical Research; 1976; 64; 1456-1461.
A method for classifying subjects as slow or rapid inactivators of isoniazid based on the ratio of acetylisoniazid to isoniazid in a 3-4 hour urine collection following an intra-muscular dose of isoniazid 3 mg./kg. body-weight has been described. Isoniazid and acetylisoniazid have been estimated using methods requiring the use of only a photo-electric colorimeter. Of the 279 patients investigated, 169 (61 per cent) were classified as slow inactivators and 110 (39 per cent) as rapid inactivators. This classification is an excellent agreement (97 per cent) with that based on a standard spectrophotometric method.
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