Cell mediated immunity in post-streptococcal glomerulonephritis.
Sarala Rajajee; Narayanan, P.R.; Moses, S.G.P; Sundaravalli, N.
Indian Paediatrics; 1984; 21; 615-621.
Cell mediated immunity was assessed in 30 children with acute post streptococcal glomerulonephritis (APSGN) in parallel with 20 normal children and 15 children without nephritis who showed evidence of skin-sore ß-Hemolytic streptococcal infection. Delayed cutaneous hypersensitivity to 2, 4 dintrochloro benezene (DNCB) was similar in the three groups. There were no significance differences in the proportional of early and total T-rosettes. Lymphocyte transformation response to phytohemagglutinin -P (PHA), purified protein derivative (PPD) and BCG was similar in them, indirect leucocyte migration inhibition response to PPD, streptokinase streptodornase (SK-SD), and group A ß-Hemolytic T 12 streptococcal antigen were not significantly different in patients when compared to normal controls and streptococcal infection controls. Cell mediated immunity was normal in APSGN in children by all the parameters studied.
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