Humoral immunity in acute post-streptococcal glomerulonephritis.
Sarala Rajajee; Narayanan, P.R.; Moses, S.G.P.; Sundaravalli, N.
Indian Paediatrics; 1984; 21; 677-681.
Humoral immune response was assessed in 60 children with acute post-streptococcal glomerulonephritis in parallel with 15 children with only skin streptococcal infection and 20 normal children.
B-lymphocytes as assessed by EAC rosettes estimation was significantly elevated in patients. Markedly high anti-D Nase B antibody titres were demonstrated in patients and to a less extent in skin infection controls, as compared to normal controls.
C 1 levels were decreased in all the patients and C 4 levels were decreased in 76%. The levels returned to normal 2 months later, C 3 and C 4 levels were normal in skin infection and normal controls.
Serum IgG, IgM, IgA were normal; in patients and Rheumatoid factor was positive in only 24% of patients, all of whom had a low positive titre.
These studies indicate marked humoral immune response to streptococcal infection in patients with APSGN, IgG anti-IgG immune complex did not play a significant role in our patients.
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