Serum protein profile in patients with pulmonary tuberculosis.
Kailasam, S.; Jayasankar, K.; Kannapiran, M.; Krishnamurthy, M.S.; Krishnamurthy, P.V.; Raghupati Sarma, G.
Indian Journal of Medical Research; 1985; 81; 551-557.
A detailed study of the alterations in the serum protein fractions following commencement of effective anti-tuberculosis treatment was undertaken in 511 patients with pulmonary tuberculosis. The concentration of serum albumin was 20-30 per cent higher (p < 0.001) and that of (1,(2 and g -globulins significantly lower at the end of treatment than admission (p < 0.01), the magnitude of decrease being 7.17 per cent for g -globulin, 19.30 per cent for(1-globulin and 35-38 per cent for (2-globulin. In all 481 patients had a favourable response to treatment, 46 of whom had a bacteriological relapse within 18 months of stopping treatment. The likelihood of a relapse was found to be greater with higher (3-globulin concentrations at the end of treatment, the proportion of patients who relapsed being 3,9, 13 and 15 per cent with (2-globulin concentrations of < 0.40, 0.40-0.59, 0.60-0.79 and >0.80 g/dl (p=0.02).
Back to List of publications / Home |