Uric acid disposition during intermittent chemotherapy of pulmonary tuberculosis with regimens containing pyrazinamide and rifampicin.
Kannapiran, M.; Krishnamurthy, P.V.; Raghupati Sarma, G.
Indian Journal of Medical Research; 1985; 82; 116-121.
Uric acid disposition during intermittent chemotherapy of pulmonary tuberculosis was studied in 13 patients allocated to a thrice-weekly regimen containing pyrazinamide in addition to rifampicin, isoniazid and streptomycin and in 19 patients allocated to a twice-weekly regimen of the same four drugs; the dosage of pyrazinamide was 50 mg/kg in the former and 70 mg/kg in the latter. In the thrice-weekly series, the mean serum uric acid concentration ½h before drug administration at 2 months (5.5 mg/dl) was significantly higher (p < 0.001) than that on admission(3.2 mg/dl); hyperuricaemia (> 7 mg/dl) was observed in none of the patients on admission and in 3 at 2 months. In the twice-weekly series, the two values (3.4 and 3.1 mg/dl, respectively) were similar, and none of the patients had hyperuricaemia. The mean concentrations 5 h after drug administration at 2 months were significantly higher (p < 0.001) than those before drug administration in both the series (6.6 and 4.8 mg/dl, respectively), and hyperuricaemia was observed in 4 patients, all in the thrice-weekly series.
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