Self-induction of rifampicin metabolism in man.
Chandra Immanuel; Jayasankar, K.; Narayana, A.S.L.; Raghupati Sarma, G.
Indian Journal of Medical Research; 1985; 82; 381-387.
Self-induction of rifampicin metabolism caused by daily administration of the drug was studied in 7 healthy subjects. Rifampicin 600 mg was administered daily for 10 days and additional dose were administered on the 4th day and 8th days after drug administration ceased. The mean serum half-life of rifampicin decreased from 4.9 h on the 1st day to 3.5 h on the 4th day (p < 0.01), to 2.7 h on the 7th day (p < 0.001), and 2.5 h on the 10th day (p < 0.001). The difference between the mean values on the 7th and the 10th days was not significant. The mean value on the 8th day after stopping drug administration (3.8 h), was significantly higher than that on the last day of daily administration (p=0.02), but was still lower than that on the 1st day (p=0.05). There was a decrease in the excretion of both rifampicin and desacetyl-rifampicin in urine on induction, followed by a gradual return to normal when drug administration was stopped.
Back to List of publications / Home |