Increased serum levels of antifilarial (IgA) antibodies in patients with tropical pulmonary eosinophilia
Ramesh Paranjape, S.; Kumaraswami, V.; Prabhakar, R.; Narayanan, P.R.
Lung India; 1985; III; 27-29.
Tropical Pulmonary Eosinophilia (TPE) is diagnosed on the basis of high peripheral eosinophilia associated with clinical symptoms and signs. Elevated levels of total and anti-filarial immunoglobulins is one of the characteristic features of TPE. Ten clinically diagnosed TPE patients and ten controls were compared for their anti-filarial and anti-ascaris antibody levels of classes IgG, IgM and IgA. While, IgG antibodies exhibited considerable cross reactivity between Ascaris and Filarial antigens, IgM antibodies showed nonspecific binding to filarial antigens. However, IgA antibodies were found to discriminate between TPE and control sera better than IgG and IgM antibodies.
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