Staff Profile

Educational Qualification

M.Sc., M.Phil.,(Biochemistry) Ph.D., (Biochemistry-Immunology, Inter-disciplinary)

Personal Statement

My research advances tuberculosis (TB) care focusing on immunodiagnostics, cellular immune responses, and host-directed therapies. I explore TB treatment monitoring markers, new immune cells, immunotherapies, immunometabolomics, and vaccine research to improve patient outcomes. Committed to translating mechanistic discoveries into clinical solutions, I aim to optimize global health strategies against this persistent pathogen and reduce the burden of tuberculosis worldwide.

Research Focus

• • Immunodiagnostics, Immune markers for TB treatment monitoring
• • Cellular immune response and exploration of new immune cells in tuberculosis
• • Immunotherapy in tuberculosis
• • Immunometabolomic exploration of tuberculosis
• • Host-directed therapies

Ongoing projects as Principal investigator

“Immunometabolomics in the quest for comprehending protection and pathogenesis in tuberculosis” (ICMR funded)

Significant Publications

• Agrawal S, Parkash O, Alangudi PN, Bhatia AK, Kumar S, Chauhan DS, Madhan Kumar M* ,Efficacy of T regulatory cells, Th17 cells and the associated markers in monitoring tuberculosis treatment response. Front. Immunol. 9:157. (Impact factor: 7.0)

• Murthy MK*, Gupta VK, Maurya AP. Metabolomics and Artificial Intelligence (AI) assisted metabolomics in the diagnosis of non-tuberculous mycobacterial infections: progress and challenges. New Microbes New Infect. 2026;71:101759. Published 2026 May 7. (Impact factor: 5.4)

• Murthy, Madhan Kumar*, Vivek Kumar Gupta, and Anand Prakash Maurya. "Diagnosis of Nontuberculous mycobacterial (NTM) infections using Genomics and Artificial Intelligence-Machine Learning Approaches: scope, progress and challenges." Frontiers in Microbiology 16 (2025): 1665685 (Impact factor: 4.5).

• Gupta VK, Kumar MM, Bisht D, Kaushik A. Plants in our combating strategies against Mycobacterium tuberculosis: progress made and obstacles met. Pharm Biol. 2017 Dec;55(1):1536-1544 (Impact factor: 4.8).

• Ramana Rao PV, Madhan Kumar M, Basirudeen S, Sharma P, Soumya S, Alamelu Raja. Improved diagnosis of tuberculosis in HIV-TB patients using RD1 encoded antigen CFP-10. Int. J Infect. Dis. 2009, 13:613-22 (Impact factor: 4.6)

• Madhan Kumar, Jagadish C Sundaramurthi, Narinder K Mehra, Gurvinder Kaur, Alamelu Raja. “Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India.” Med Microbiol Immunol. 2010 Feb;199(1):11-25 (Impact factor: 3.1).

• M. Madhan Kumar, Alamelu Raja. Cytotoxicity responses to selected ESAT-6 and CFP-10 peptides in tuberculosis Cell Immunol. 2010;265 (2):146-55 (Impact factor: 3.3).

• Madhan Kumar, Meenakshi N, Jagadish C Sundaramurthi , Gurvinder Kaur, Narinder K Mehra, Alamelu Raja. “Immune response to Mycobacterium tuberculosis specific antigen ESAT-6 among south Indians.” Tuberculosis (Edinb). 2010 Jan;90(1):60-9. Epub 2009 Nov 27 (Impact factor: 2.9).

• Agrawal S, Parkash O, Palaniappan AN, Bhatia AK, Kumar S, Chauhan DS, Madhan Kumar M* (Corresponding author) The role of T regulatory cell-associated markers in monitoring tuberculosis treatment completion and failure. Immunol Res. 2018 Oct;66(5):620-631. doi: 10.1007/s12026-018-9022-7 (Impact factor: 2.7).

• Gupta VK, Kumar MM, Singh D, Bisht D, Sharma S. Drug targets in dormant Mycobacterium tuberculosis: can the conquest against tuberculosis become a reality?. Infect Dis (Lond). 2018; 50(2): 81-94. (Impact factor: 2.3)

Awards and Honours

• Awardee of Junior research fellowship from Council of Scientific and Industrial Research (CSIR), Government of India, a national level eligibility test held on June 2003 for pursuing my PhD (Selected to appear for Shyama Prasad Mukherjee fellowship examination for top 20% performance in NET exam).

• Received by the PhD student Ms. Sonali Agrawal working in my project who presented a poster in Immunocon 2017 (14-16 December 2017 at Ahmedabad), a part of my DRDE project work entitled “T cell associated biomarkers for monitoring treatment efficacy in Tuberculosis”.

Research Profiles